The ARNT Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to ARNT. This antibody recognizes Human, Mouse, and Rat antigen. The ARNT Antibody has been validated for the following applications: Western Blot.
Description
Required for activity of the Ah (dioxin) receptor. This protein is required for the ligand-binding subunit to translocate from the cytosol to the nucleus after ligand binding. The complex then initiates transcription of genes involved in the activation of PAH procarcinogens. The heterodimer with HIF1A or EPAS1/HIF2A functions as a transcriptional regulator of the adaptive response to hypoxia.Hoffman E.C., Science 252:954-958(1991).Wang G.L., Proc. Natl. Acad. Sci. U.S.A. 92:5510-5514(1995).Nguyen T.A., Arch. Biochem. Biophys. 367:250-257(1999)